Ongoing
Objective: The purpose of the study is to assess the neuroprotective, anti atherogenic and hepatoprotective properties of tocotrienols (palm vitamin E) supplementation as determined by white matter lesion load on serial magnetic resonance imaging (MRI), carotid artery magnetic resonance angiography (MRA) and liver ultrasound (US) as well as lipid profile analysis.
Study Type: Interventional
Study Design: Phase 2, Randomized, Double –Blind
Subjects: Patients with cerebrovascular disorders
Intervention: Tocotrienol, placebo
Primary Outcome: Regression of white matter lesion load in terms of numbers and size in the brain [ Time Frame: 1 to 2 years ]
Secondary Outcome: 1) Regression of the carotid artery stenoses in terms of percentage [ Time Frame: 1 to 2 years ]
2) The improvement in the lipid profile other markers associated with increased cardiovascular risk [ Time Frame: 1 to 2 years ]
3) Improvement in liver echogenicity. [ Time Frame: 1 to 2 years ] [ Designated as safety issue: No ]