The underrated antioxidant to hydrate weak, brittle nails

When it comes to nails, one has to be careful with the type of nail polish they put. A high-quality liquid is important and protecting the nails from becoming soft is certainly vital for its growth.

es, as much as your skin needs hydration from time to time, even your nails need to be moisturised to keep them healthy and shiny. The one ingredient that is an antioxidant that protects your cuticles is vitamin E or moisture-rich tocopherol, which is a fat-soluble vitamin. It helps to even out the nail plate (the hard part of the nail).

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Water-soluble vitamin E compounds directly inhibit SARS-CoV-2 replication and synergize with remdesivir

Researchers in the United States have shown that water-soluble derivatives of vitamin E (α-tocopherol) exhibit potent antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

Kevin Harrod from the University of Alabama at Birmingham and colleagues found that the compounds synergized with the antiviral drug remdesivir to inhibit SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) – an enzyme that is crucial for transcription and replication of the viral genome.

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Making sense of antisense gene silencing

Antisense oligonucleotide (ASO) therapies use small strands of DNA or RNA that are antisense, or complementary, to the associated gene to interfere with its expression. ASO therapies are already available for some diseases, particularly neurological disorders, but their use is at a very early stage. It is known that modifying ASOs chemically can improve the efficacy of the therapy. The team at TMDU had previously achieved gene silencing by attaching alpha-tocopherol (Toc) to ASOs. They then created Toc-HDOs by attaching Toc to DNA/RNA heteroduplex oligonucleotides, which are double-stranded molecules consisting of one strand of DNA and one strand of RNA. Toc-HDOs are more potent, stable, and efficiently taken up by target tissues than ASOs, and so have great therapeutic potential.

 

 

 

 

 

 

 

 

 

 

 

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Annatto tocotrienol may help manage blood sugar: RCT

Supplementation with annatto-derived delta-tocotrienol may improve glucose control, inflammation and oxidative stress in people with type 2 diabetes mellitus (T2DM), says a new study from the National University of Medical Sciences in Pakistan.

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Tocotrienols Show Benefits for Patients with Type 2 Diabetes Mellitus in Clinical Study

Delta-tocotrienol from annatto has been shown in a new clinical study to improve glycemic control, inflammation, and oxidative stress in patients diagnosed with type 2 diabetes mellitus, according to a press release from American River Nutrition.

The randomized, double-blind, placebo-controlled trial was published in Phytotherapy Research. It was performed on 110 patients with T2 diabetes. For 24 weeks, the patients received either a placebo or 250mg/day of DeltaGold tocotrienols. The participants were encouraged to perform regular physical activity, and continued using their typical hypoglycemic agents without insulin usage.

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How COVID-19 revitalized interest in familiar letter vitamins

Back-to-basics As, Bs, and Cs (and Ds, and Ks, and Es) are basking in vitamins’ newfound glow.

Jia Zhang Lee, executive director, Davos Life Science (Singapore), notes that his company has seen a steady increase in demand for vitamin E tocotrienols in particular. “Research studies have shown that tocotrienols have positive health benefits in the management of hypertension, heart disease, and diabetes,” Lee notes. “These chronic conditions predispose individuals to the more severe form of COVID-19, and therefore there’s been growing interest in tocotrienol supplementation to help promote the prevention of these chronic diseases.”

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