Water-soluble vitamin E compounds directly inhibit SARS-CoV-2 replication and synergize with remdesivir

Researchers in the United States have shown that water-soluble derivatives of vitamin E (α-tocopherol) exhibit potent antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

Kevin Harrod from the University of Alabama at Birmingham and colleagues found that the compounds synergized with the antiviral drug remdesivir to inhibit SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) – an enzyme that is crucial for transcription and replication of the viral genome.

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Annatto tocotrienol may help manage blood sugar: RCT

Supplementation with annatto-derived delta-tocotrienol may improve glucose control, inflammation and oxidative stress in people with type 2 diabetes mellitus (T2DM), says a new study from the National University of Medical Sciences in Pakistan.

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Tocotrienols Show Benefits for Patients with Type 2 Diabetes Mellitus in Clinical Study

Delta-tocotrienol from annatto has been shown in a new clinical study to improve glycemic control, inflammation, and oxidative stress in patients diagnosed with type 2 diabetes mellitus, according to a press release from American River Nutrition.

The randomized, double-blind, placebo-controlled trial was published in Phytotherapy Research. It was performed on 110 patients with T2 diabetes. For 24 weeks, the patients received either a placebo or 250mg/day of DeltaGold tocotrienols. The participants were encouraged to perform regular physical activity, and continued using their typical hypoglycemic agents without insulin usage.

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What are the benefits of vitamin E for the skin?

Vitamin E is an antioxidant that can help fight free radicals, which are molecules that damage the DNA in cells. People can usually get adequate vitamin E from their diet, but it is also available in the form of supplements and skin care products.

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How COVID-19 revitalized interest in familiar letter vitamins

Back-to-basics As, Bs, and Cs (and Ds, and Ks, and Es) are basking in vitamins’ newfound glow.

Jia Zhang Lee, executive director, Davos Life Science (Singapore), notes that his company has seen a steady increase in demand for vitamin E tocotrienols in particular. “Research studies have shown that tocotrienols have positive health benefits in the management of hypertension, heart disease, and diabetes,” Lee notes. “These chronic conditions predispose individuals to the more severe form of COVID-19, and therefore there’s been growing interest in tocotrienol supplementation to help promote the prevention of these chronic diseases.”

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The Health Benefits of Tocotrienol

Tocotrienols are chemicals in the vitamin E family. Unlike other forms of vitamin E, tocotrienols are less commonly found in nature. Most of the food we eat contains tocopherols instead of tocotrienols, but several types of vegetable oils, like palm oil, contain high amounts of tocotrienols. Most vitamin E supplements contain tocopherols and not tocotrienols. Studies also suggest that tocotrienol is a more potent form of vitamin E than tocopherol. Research also tells us that tocotrienol has many health benefits.

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MPOB develops three palm-based technologies for commercialisation

The Malaysian Palm Oil Board (MPOB) has developed three advanced palm-based technologies for commercialisation.

In a statement on Friday, it said the first is the process and formulation of palm vitamin E/ tocotrienol-rich fraction (TRF) chewable tablet. The second is palm oil-based polyol for floor coverings for indoor and outdoor and sports flooring markets while the third is a moisturising hand sanitiser with Vitamin E. MPOB said the three are among the technologies approved by the Minister of Plantation Industries and Commodities for commercialisation.

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Vitamin E from palm oil useful in boosting immune response based on studies on liver cells

A team of researchers from Malaysia and Libya recently investigated the effect of tocotrienols extracted from palm oil on mice liver cells. The team investigated the expression levels of genes influenced by a transcription factor Nrf2, and the translocation of the same factor into the cellular nucleus. Nrf2 is known to upregulate phase II drug metabolism in reaction to metabolic processes. The genes activate cellular defense mechanisms. “Our study is the first in vivo study on the effect of tocotrienols on Nrf2on genetic material in the nucleus.,” says Azman Abdullah (Universiti Kebangsaan Malaysia), corresponding author of the study.

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