A combination of tocotrienols and alpha-tocopherol may help support endothelial function, but the effects were not observed when the tocotrienols were used alone, says a new study.
DETROIT – End-stage renal disease (ERSD) is the last stage of chronic kidney disease where the kidneys function at under 10 to 15 percent of their normal capacity. At this stage, kidneys cannot effectively remove waste or excess fluid from the blood system, and dialysis or a kidney transplant is necessary to live.
A team of researchers led by Pramod Khosla, Ph.D., associate professor of nutrition and food science in the College of Liberal Arts and Sciences at Wayne State University, will study the effects of a daily supplement of a Tocotrienol-rich fraction from palm oil to see if it improves dyslipidemia, a disorder of lipoprotein metabolism that may be manifested by a decrease in the “good” high-density lipoprotein (HDL) cholesterol in patients with ESRD who are on hemodialysis. Tocotrienols are a form of Vitamin E and have been shown in recent years to have diverse health effects. In addition, Khosla’s team will explore the impact on symptoms such as inflammation and symptoms related to Restless Leg Syndrome in the same cohort of patients.
Researchers from the University of Florida report that gamma-tocotrienol from red palm oil accumulates in adipose tissues, slowing down high-fat diet-induced obesity and improving insulin sensitivity in mice by inhibiting adipose inflammation.
In the new study, Dr. SK Chung and her team investigated the effects of gamma-tocotrienol on early onset obesity, inflammation, and insulin resistance in mice. The mice were randomly assigned to three different diet groups – low fat (LF), high fat (HF) with 60% calories from fat, or HF mixed with 0.05% gamma-tocotrienol, one of eight different compounds that make up natural vitamin E. Measurements of gamma-tocotrienol concentrations in blood and adipose tissue; effects of gamma-tocotrienol on body weight gain, adipose volume, fasting blood glucose, insulin level and various inflammatory biomarkers were recorded.
Numerous studies over the past two decades have clearly proven that the tocotrienol form of vitamin E is a top choice for cardiovascular protection and heart health. A recent review of tocotrienol science points out that they are also being researched for benefits to bone health, blood sugar metabolism, brain health, and cancer. Tocotrienols offer a safe and effective way to help achieve or maintain healthy cholesterol, while simultaneously protecting your arteries. It is worthwhile understanding more about them and how they can improve your health.
WHO report states that cardiovascular disease (CVD) remains a leading cause of death and disability worldwide. Though preventable, an expected 23.6 million people will die mainly from CVD by 2030. To help support cardiovascular health, the majority of nutraceuticals are directed towards promoting heart and blood vessel health through reduction in the level of body lipids such as cholesterol and triglyceride.
Byron J. Richards
The tocotrienol form of vitamin E is now on an anti-aging tear. Recently I reported how this form of vitamin E was shown to extend the length of telomeres, enabling cells to live longer. A new human study shows that it boosts protective HDL Cholesterol while lowering a key marker of aging – advanced glycation end products. A new animal experiment shows that tocotrienols significantly reduce the damage from experimentally induced stroke. These new studies add even more evidence of the extreme health benefits offered by this special form of vitamin E, as I extensively reviewed in my previous article, Tocotrienols: Twenty Years of Dazzling Cardiovascular and Cancer Research.
Few people pay attention to the importance of vitamin E, much less to the multi-fractioned mirror image versions of the vitamin known as isomers (consisting of tocotrienols and tocopherols). Vitamin E has long been known as a nutrient that may play a role in maintaining heart health, but extensive new research explains that the vitamin in all its potent forms is required to dramatically lower the risk of heart disease and heart attack.
Extensive Big Pharma propaganda has most allopathic physicians and their patients focused on blood cholesterol levels as a critical factor in cardiovascular disease development, as this is a number they can easily manipulate with dangerous statin drugs. Extensive scientific research points to increased levels of blood fat triglycerides as a primary cause of heart disease, cognitive decline, dementia and metabolic syndrome leading to diabetes.