Research Letter

Systemic sclerosis, is a progressive connective tissue disease characterised by extensive fibrosis and affects skin as well as various internal organs.1 Skin fibrosis, a highly recognised feature of systemic sclerosis, causes significant physical disability and psychological disorder but is difficult to treat.2 Recently, vitamin E, a natural antioxidant, has been demonstrated to exert anti-fibrotic properties in vitro and in some fibrotic diseases.3-5 This study aimed to investigate the effects of vitamin E on skin fibrosis in bleomycin-induced mouse model of scleroderma and to clarify the underlying mechanisms.