Abstract
BACKGROUND:
Coumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity a series of new bio-antioxidants has been designed.
RESULTS:
New antioxidant compositions (equimolar binary and ternary mixtures) of eight 4-methylcoumarins and three related compounds have been tested and different effects between the individual components have been observed: positive effect (synergism), summary effect (additivism) and negative effect (antagonism). Higher oxidative stability of lipid substrate was obtained in presence of the new antioxidant compositions of studied compounds with DL-α-tocopherol and L-ascorbic acid. The role of each component in the antioxidant compositions of ternary mixtures has been identified by using new equations composed by us.
CONCLUSIONS:
All the ternary mixtures demonstrate synergism as a result of a continuous regeneration of DL-α-tocopherol from the studied antioxidants and L-ascorbic acid. Theoretical calculations have been probed in the prediction of the expected effects between the individual components in a double mixture.