Vitamins are prominent among natural or endogenous compounds that are considered to be beneficial for both prevention and therapy of various human ailments. The vitamin E group of compounds composed of tocopherol and tocotrienol isoforms, has been subsequently proven to have health benefits including antioxidant and related protective properties. The anticancer effect of T3 remains not fully understood but generally is mediated independently of its antioxidant activity. In this study, new redox-inactive analogue of T3, 6-O-carboxypropyl-alpha-tocotrienol (T3E) showed considerable promise for stronger anticancer potency than its mother compound.
