Vitamin E inhibits protein oxidation in skeletal muscle of resting and exercised rats

Reznick AZ, Witt E, Matsumoto M, Packer L.

Biochem Biophys Res Commun. 1992 Dec 15;189(2):801-6.

It is well known that exercise induces lipid peroxidation in skeletal muscle and that vitamin E prevents exercise-induced lipid damage. In this study we show for the first time, an increase in protein oxidation in skeletal muscle after a single bout of exercise, related to an exercise-induced decrease in lipophilic antioxidants, and substantial protection against both resting and exercise-induced protein oxidation by supplementation with various isomers (alpha-tocopherol, alpha-tocotrienol) of vitamin E.