Monthly Archives: December 2015

The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model.

Ibrahim N, Mohamed N, Soelaiman IN, Shuid AN.

Int J Environ Res Public Health. 2015 Oct 16;12(10):12958-76

Abstract

Osteoporotic drugs are used to prevent fragility fractures, but their role in fracture healing still remains unknown. Thus, alternative agents with suitable mode of delivery are needed to promote fracture healing. This study was performed to investigate the effects of direct deliveries of lovastatin and tocotrienol to fracture sites on ossification-related gene expression in fracture healing in a postmenopausal osteoporosis model. Forty-eight Sprague Dawley female rats were divided into six groups. Group I comprised the sham-operated rats, while Groups II-VI were ovariectomized rats. After 8 weeks, the right tibiae of all rats were fractured and stabilized. Group I and Group II were given two single injections of lovastatin andtocotrienol carriers. Group III was given an estrogen preparation at 64.5 µg/kg daily via oral gavages. Group IV was injected with lovastatin particles (750 µg/kg), while Group V was injected with tocotrienol particles (60 mg/kg). Group VI received two single injections of 750 µg/kg lovastatin particles and 60 mg/kg tocotrienol particles. After 4 weeks, the gene expressions were measured. Group VI showed significantly higher gene expressions of osteocalcin, BMP-2, VEGF-α, and RUNX-2 compared to Group II. In conclusion, combined treatment of lovastatin and tocotrienol upregulated the expression of genes related to fracture healing.

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This Vitamin Can Save Your Brain

vitamin-repair-brain-damage

Your brain has amazing abilities. And it can heal itself.

That’s not something you’re likely to hear from mainstream medicine — especially if you or a loved one suffer from the effects of stroke, Alzheimer’s, Parkinson’s or another form of dementia.

Here at the Sears Institute for Anti-Aging Medicine, I’ve seen many people with brain damage. And, sadly, most have been deemed “hopeless” by so-called medical experts.

But I can tell you there is nothing hopeless about dementia — no matter what its cause. With the right nutrients, there are times when brain damage can be reversed.

And now recent research from a university in Malaysia backs up what I’ve observed for years in my own clinic.

These new studies show that one, special vitamin not only prevents brain damage, but it can help repair it.

I’m talking about an overlooked form of vitamin E called tocotrienols.

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True Value of Palm Oil

Dr Jean Graille, a world renowned biotechnology expert who focuses on fats and lipids, completed his studies at the Ecole Nationale Supérieure de Chimie de Marseille [National Chemical Engineering Institute of Marseilles]. He began working as a researcher at the Institut des Corps Gras [Institute for Fats and Oils] before continuing his career in the Agribusiness Programme of CIRAD, where he managed the team for ‘Food and Non-Food Substances – Lipid Technology Sciences’. Dr Graille won the Chevreul medal in 1997 and went on to receive the Kaufmann Prize in 1999 – the first French person to do so. In an interview, he dismantles the myths perpetuated by the anti-palm oil lobby in France, and issues the timely reminder that there is no justification to avoid the use of this important product.

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