Monthly Archives: January 2017

6 Signs Of Vitamin E Deficiency; Symptoms Include Miscarriage

When a fetus isn’t getting enough vitamin E, the pregnant mother could miscarry because the deficiency prevents crucial body parts from developing, according to a study in Free Radical Biology and Medicine.

Researchers recently discovered the process, which is just one of many negative side effects of not having enough vitamin E. Oregon State University said in a statement that “severe vitamin E deficiency causes the depletion of essential fatty acids,” forcing cells to rely on glucose to prevent damage. “Lacking glucose for energy, many physical and neurologic features, especially the brain, simply don’t get built, and death can be the result.”

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Vitamin E deficiency linked to embryo damage, death

Researchers for the first time have explained how deficient levels of vitamin E can cause neurologic damage to an embryo, failure to normally develop and ultimately death – a process that in women can be one cause of miscarriage. The research was published by scientists from Oregon State University in Free Radical Biology and Medicine. It answers some questions about the biologic activities of vitamin E that have been debated since 1922, when this essential micronutrient was first discovered, in part for its role in preventing embryonic mortality.

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Mono-epoxy-tocotrienol-α enhances wound healing in diabetic mice and stimulates in vitro angiogenesis and cell migration.

Xu C, Bentinger M, Savu O, Moshfegh A, Sunkari V, Dallner G, Swiezewska E, Catrina SB, Brismar K, Tekle M.

J Diabetes Complications. 2017 Jan;31(1):4-12. doi: 10.1016/j.jdiacomp.2016.10.010. Epub 2016 Oct 18.

Abstract

Diabetes mellitus is characterized by hyperglycemia and capillary hypoxia that causes excessive production of free radicals and impaired antioxidant defense, resulting in oxidative stress and diabetes complications such as impaired wound healing. We have previously shown that modified forms of tocotrienols possess beneficial effects on the biosynthesis of the mevalonate pathway lipids including increase in mitochondrial CoQ. The aim of this study is to investigate the effects of mono-epoxy-tocotrienol-α on in vitro and in vivo wound healing models as well as its effects on mitochondrial function. Gene profiling analysis and gene expression studies on HepG2 cells and human dermal fibroblasts were performed by microarray and qPCR, respectively. In vitro wound healing using human fibroblasts was studied by scratch assay and in vitro angiogenesis using human dermal microvascular endothelial cells was studied by the tube formation assay. In vivo wound healing was performed in the diabetic db/db mouse model. For the study of mitochondrial functions and oxygen consumption rate Seahorse XF-24 was employed. In vitro, significant increase in wound closure and cell migration (p<0.05) both in normal and high glucose and in endothelial tube formation (angiogenesis) (p<0.005) were observed. Microarray profiling analysis showed a 20-fold increase of KIF26A gene expression and 11-fold decrease of lanosterol synthase expression. Expression analysis by qPCR showed significant increase of the growth factors VEGFA and PDGFB. The epoxidated compound induced a significantly higher basal and reserve mitochondrial capacity in both HDF and HepG2 cells. Additionally, in vivo wound healing in db/db mice, demonstrated a small but significant enhancement on wound healing upon local application of the compound compared to treatment with vehicle alone. Mono-epoxy-tocotrienol-α seems to possess beneficial effects on wound healing by increasing the expression of genes involved in cell growth, motility and angiogenes as well as on mitochondrial function.

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Natural Source Vitamin E Market – Global Industry Analysis 2024

The global market for natural source vitamin E is largely driven by a substantial rise in the healthcare awareness among the global population, strengthening distribution channels, and rising affordability of products. The market struggles from the declining supply of deodorized distillates, which are the key raw materials used for manufacturing natural vitamin E, which is resulting in increased costs of products.

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Tocotrienols: the vitamin that’s making headlines. Here’s why.

You may be reading and hearing more about tocotrienols. This less-common form of vitamin E has earned the attention of researchers, health experts and the media because it’s a potent antioxidant. Studies have shown that premium tocotrienol supplements, derived from Malaysian certified sustainable palm oil, may help protect your brain from stroke damage, promote younger skin, support liver health and even reduce cancer risk.

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α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress.

Zakharova IO, Sokolova TV, Vlasova YA, Bayunova LV, Rychkova MP, Avrova NF.

Int J Mol Sci. 2017 Jan 21;18(1). pii: E216. doi: 10.3390/ijms18010216.

Abstract

The aim of the present work is to study the mechanism of the α-tocopherol (α-T) protective action at nanomolar and micromolar concentrations against H₂O₂-induced brain cortical neuron death. The mechanism of α-T action on neurons at its nanomolar concentrations characteristic for brain extracellular space has not been practically studied yet. Preincubation with nanomolar and micromolar α-T for 18 h was found to increase the viability of cortical neurons exposed to H₂O₂; α-T effect was concentration-dependent in the nanomolar range. However, preincubation with nanomolar α-T for 30 min was not effective. Nanomolar and micromolar α-T decreased the reactive oxygen species accumulation induced in cortical neurons by the prooxidant. Using immunoblotting it was shown that preincubation with α-T at nanomolar and micromolar concentrations for 18 h prevented Akt inactivation and decreased PKCδ activation induced in cortical neurons by H₂O₂. α-T prevented the ERK1/2 sustained activation during 24 h caused by H₂O₂. α-T at nanomolar and micromolar concentrations prevented a great increase of the proapoptotic to antiapoptotic proteins (Bax/Bcl-2) ratio, elicited by neuron exposure to H₂O₂. The similar neuron protection mechanism by nanomolar and micromolar α-T suggests that a “more is better” approach to patients’ supplementation with vitamin E or α-T is not reasonable.

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Best Vitamins for Acne Prone Skin 2017

Vitamin E is a powerful antioxidant which is fat soluble. It is one of the best vitamins for acne which protects skin cells from damage and helps them heal more quickly. Vitamin E enhances tissue repair and healing. Vitamin E acne treatments also inhibit the formation of free radicals, thereby protecting skin from external aggressors.

Some common dietary sources of vitamin E for acne are wheat germ oil, sunflower oil, and sunflower oil. Other sources of vitamin E are green leafy vegetables, hazelnuts, almonds, avocados, mangos, pumpkin and palm oil. Vitamin E is also essential for proper neurological function and enzyme activity.

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Benefits of facial oil in daily beauty regime

Vitamin E is highly beneficial as it is a powerful anti-oxidant that helps repair cell damage. Facial oils usually have the ever nourishing vitamin E, marula oil, Argan oil, rosehip, camellia, black cumin among other things.

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Vitamin E supplementation modulates the biological effects of omega-3 fatty acids in naturally aged rats.

Narayanankutty A, Kottekkat A, Mathew SE, Illam SP, Suseela IM, Raghavamenon AC.

Toxicol Mech Methods. 2017 Jan 8:1-8. doi: 10.1080/15376516.2016.1273431. [Epub ahead of print]

Abstract

Omega-3 fatty acids are well-known class of nutraceuticals with established health benefits. Recently, the oxidation products of these fatty acids are gaining attention, as they are likely to disturb body redox balance. Therefore, the efficacy of omega-3 fats under conditions of diminished antioxidant status, such as aging, is always a concern. Present study assessed the effects of omega-3 fats (DHA and EPA) together with or without vitamin-E in naturally aged rats. It was found that in omega-3 fats alone consumed rats the lipid profile was improved, while in omega-3 fat with vitamin-E-consumed group (OMVE), the hepato protective and antioxidant properties were pronounced, especially the redox status of brain tissue. It is possible that vitamin-E might have reduced the peroxidation of omega-3 fats, thereby allowing their synergistic effects. Hence, the use of vitamin-E along with omega-3 fat may be beneficial under aged conditions.

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