Blog Archives

Advances in Genetic Improvement for Tocotrienol Production: A Review.

Babura SR, Abdullah SNA, Khaza Ai H

J Nutr Sci Vitaminol (Tokyo). 2017;63(4):215-221. doi: 10.3177/jnsv.63.215.

Abstract

Tocotrienols are forms of vitamin E that are present in several important food crops. Compared to tocopherols, less research has been conducted on these compounds because of their low bioavailability and distribution in plant tissues. Both tocotrienols and tocopherols are known for their antioxidant and anticancer activities, which are beneficial for both humans and animals. Moreover, tocotrienols possess certain properties which are not found in tocopherols, such as neuroprotective and cholesterol-lowering activities. The contents of tocotrienolsin plants vary. Tocotrienols constitute more than 70% and tocopherols less than 30% of the total vitamin E content in palm oil, which is the best source of vitamin E. Accumulation of tocotrienols also occurs in non-photosynthetic tissues, such as the seeds, fruits and latex of some monocotyledonous and dicotyledonous plant species. The use of biotechnological techniques to increase the tocotrienol content in plants, their biological functions, and benefits to human health are discussed in this review.

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GMO tomato created with dramatically higher vitamin levels, antioxidant properties

The School of Biological Sciences, Faculty of Science, the University of Hong Kong (HKU), in collaboration with the Institut de Biologie Moléculaire des Plantes (CNRS, Strasbourg, France), has identified a new strategy to simultaneously enhance health-promoting vitamin E by ~6-fold and double both provitamin A and lycopene contents in tomatoes, to significantly boost antioxidant properties.

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Experimental ‘golden’ potato could hold power to prevent disease in developing nations

An experimental “golden” potato could hold the power to prevent disease and death in developing countries where residents rely heavily upon the starchy food for sustenance, new research suggests.

A serving of the yellow-orange lab-engineered potato has the potential to provide as much as 42 percent of a child’s recommended daily intake of vitamin A and 34 percent of a child’s recommended intake of vitamin E, according to a recent study co-led by researchers at The Ohio State University.

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How Tocopherols mixed Market will Grow in Future? PMR Research Offers Insights 2017 – 2025

Global citizens are more aware of their health and governments around the world laid several rules to stall the use of harmful preservatives in food products. The new crop of organic foods is in high demand in the global food and beverage markets. These elements are playing a significant role in the growth of the natural preservatives such as Tocopherols (mixed). There has been a considerable rise in the use of natural foods which has positively affected the use of natural and no harmful preservatives. The market of the natural preservatives such as Tocopherols (mixed) reaping the benefits of this new environment-friendly preservatives market.

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Tocotrienols Dalam Vitamin E Bisa Turunkan Risiko Stroke

Sejumlah penelitian menunjukkan bahwa tocotrienols yang terkandung dalam vitamin E bisa melindungi otak dari kerusakan akibat stroke dan mengurangi risiko stroke rekuren.

“Kerusakan otak saat stroke bisa dicegah dengan memicu pembuluh darah disekitarnya untuk melebarkan dan mengarahkan aliran darah disekitar penyumbatan,” kata peneliti tocotrienol, Professor Chandan K. Sen, seperti dilansir laman MSN, Selasa (7/11).

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δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice.

Wang H, Yang X, Liu A, Wang G, Bosland MC, Yang CS

Carcinogenesis. 2017 Nov 7. doi: 10.1093/carcin/bgx128.

Abstract

The PTEN/PI3K/AKT axis plays a critical role in regulating cell growth, differentiation and survival. Activation of this signaling pathway is frequently found in human cancers. Our previous studies demonstrated that δ-tocopherol (δ-T) attenuates the activation of AKT by growth factor in prostate cancer cell lines, leading to inhibition of proliferation and induction of apoptosis. Herein, we investigated whether δ-T inhibits the development of prostate adenocarcinoma in prostate-specific Pten-/- (Ptenp-/-) mice in which the activation of AKT is the major driving force for tumorigenesis. By feeding Ptenp-/- mice with AIN93M or 0.2% δ-T supplemented diet starting at the age of 6 or 12 weeks, we found that δ-T treatment reduced prostate adenocarcinoma multiplicity at the age of 40 weeks by 53.3% and 42.7%, respectively. Immunohistochemical analysis demonstrated that the phosphorylation of AKT(T308) was reduced in the prostate of the mice administered the δ-T diet. Consistently, proliferation was reduced and apoptosis was increased in prostate lesions of mice on the δ-T diet. Oxidative stress, as determined by immunohistochemical staining of 8-OH-dG, was not altered during prostate tumorigenesis, nor was it affected by administration of δ-T. In contrast, α-tocopherol (δ-T) at 0.2% in the diet did not affect prostate adenocarcinoma multiplicity in the Ptenp-/- mice. This finding is consistent with data from our previous study that δ-T, but not δ-T, inhibits the activation of AKT and the growth of prostate cancer cells. Together, these results demonstrate that δ-T inhibits the development of prostate adenocarcinoma in Ptenp-/- mice, mainly through inhibition of AKT activation.

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Hemin- and myoglobin-catalyzed reaction of 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine 13-hydroperoxide with γ-tocopherol in micelles and liposomes.

Yamauchi R, Kinoshita T, Hasegawa Y, Iwamoto S

Chem Phys Lipids. 2017 Nov 7;209:37-44. doi: 10.1016/j.chemphyslip.2017.11.005.

Abstract

The secondary process of lipid peroxidation proceeds by the free radical reaction to produce some toxic aldehydes. Since γ-tocopherol (γ-TH), one of the major forms of vitamin E in some vegetable oils, acts as a free radical scavenger, γ-TH may suppress the formation of such aldehydes. This study reports the effect and reaction products of γ-TH on the hemin- or myoglobin-catalyzed decomposition of 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine 13-hydroperoxide (PLPC-OOH) in micelles and liposomes. γ-TH and PLPC-OOH in micelles were reacted in the presence of hemin, and the reaction products were characterized as 1-palmitoyl-2-[(8a-dioxy-γ-tocopherone)-12,13-epoxyoctadecenoyl]-3-sn-phosphatidylcholines (γT-OO-epoxyPLPC), 1-palmitoyl-2-[(γ-tocopheroxy)-12,13-epoxyoctadecenoyl]-3-sn-phosphatidylcholines (γT-epoxyPLPC), and the adducts of γ-TH dimer with PLPC-OOH derived epoxyperoxyl and epoxyalkyl radicals (γTD-OO-epoxyPLPC and γTD-epoxyPLPC). The hemin- and myoglobin-catalyzed decomposition of PLPC-OOH in micelles produced hexanal and 4-hydroxy-2-nonenal as the major aldehydic products. γ-TH suppressed the formation of these aldehydes as the same level as α-TH did, and γ-tocopherylquinone, tocored, γ-TH dimers, and the addition products (γT-OO-epoxyPLPC, γT-epoxyPLPC, γTD-OO-epoxyPLPC, and γTD-epoxyPLPC) were formed during the reaction. In liposomes, hexanal was detected as the major aldehyde and its suppression by γ-TH was less effective than that by α-TH. The results indicate that γ-TH may suppress the formation of aldehydes by trapping the epoxyperoxyl and epoxyalkyl radicals derived from PLPC-OOH although its ability is weak in liposomal systems.

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Why your horse needs vitamin E

Vitamin E helps keep a horse’s muscles, nerves and all his internal workings functioning smoothly. And if he’s not getting it naturally in a green pasture, then you’ll need to find a way to add it to his diet. Here’s a look at what vitamin E does and what you can do to make sure your horse gets enough—but not too much.

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A green multicomponent synthesis of tocopherol analogues with antiproliferative activities.

Ingold M, Dapueto R, Victoria S, Galliusi G, Batthyàny C, Bollati-Fogolín M, Tejedor D, García-Tellado F, Padrón JM, Porcal W, López GV

Eur J Med Chem. 2017 Nov 3. pii: S0223-5234(17)30888-7. doi: 10.1016/j.ejmech.2017.11.003.

Abstract

A one-pot efficient, practical and eco-friendly synthesis of tocopherol analogues has been developed using water or solvent free conditions via Passerini and Ugi multicomponent reactions. These reactions can be optimized using microwave irradiation or ultrasound as the energy source. Accordingly, a small library of 30 compounds was prepared for biological tests. The evaluation of the antiproliferative activity in the human solid tumor cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast), and WiDr (colon) provided lead compounds with GI50 values between 1 and 5 μM. A structure-activity relationship is also discussed. One of the studied compounds comes up as a future candidate for the development of potent tocopherol-mimetic therapeutic agents for cancer.

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