Dr. Barrie Tan, founder of American River Nutrition and notable expert in the field of vitamin E tocopherols and tocotrienols, recently presented a live web seminar to the members of the American Academy of Nutrition and Dietetics entitled Vitamin E: Setting the Record Straight.
Blog Archives
Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.
Burbank AJ, Duran CG, Pan Y, Burns P, Jones S, Jiang Q, Yang C, Jenkins S, Wells H, Alexis N, Kesimer M, Bennett WD, Zhou H, Peden DB, Hernandez ML.
J Allergy Clin Immunol. 2017 Jul 20. pii: S0091-6749(17)31110-7. doi: 10.1016/j.jaci.2017.06.029. [Epub ahead of print]
Abstract
BACKGROUND:
We and others have shown that the gamma tocopherol (γT) isoform of vitamin E has multiple anti-inflammatory and antioxidant actions and that γT supplementation reduces eosinophilic and endotoxin (LPS)-induced neutrophilic airway inflammation in animal models and healthy human volunteers.
OBJECTIVE:
To determine if γT supplementation reduces eosinophilic airway inflammation and acute neutrophilic response to inhaled LPS challenge in volunteers with asthma.
METHODS:
Participants with mild asthma were enrolled in a double-blinded, placebo controlled crossover study to assess the effect of 1200 mg of γT daily for 14 days on sputum eosinophils, mucins and cytokines. We also assessed the effect on acute inflammatory response to inhaled LPS challenge following γT treatment, focusing on changes in sputum neutrophilia, mucins and cytokines. Mucociliary clearance was measured using gamma scintigraphy.
RESULTS:
Fifteen subjects with mild asthma completed both arms of the study. Compared to placebo, γT notably reduced pre-LPS challenge sputum eosinophils and mucins, including MUC5AC, and reduced LPS-induced airway neutrophil recruitment 6 and 24-hours after challenge. Mucociliary clearance was slowed 4-hours post-challenge in the placebo group but not in the γT treatment group. Total sputum mucins (but not MUC5AC) were reduced at 24-hours post-challenge during γT treatment compared to placebo.
CONCLUSION:
γT supplementation for 14 days reduced inflammatory features of asthma, including sputum eosinophils and mucins, as well as acute airway response to inhaled LPS challenge when compared to placebo. Larger scale clinical trials are needed to assess the efficacy of γT supplements as a complementary or steroid-sparing treatment for asthma.
Walnuts lower cardiovascular disease risk by boosting endothelial function: China meta-analysis
Consuming walnuts could help lower the risk of cardiovascular diseases by improving endothelial function, according to new Chinese analysis, which didn’t find the same specific effect from almonds, hazelnuts or pistachios.
The top ingredients for cognition, focus & mood
Memory, attention and focus, development, mood; there are numerous ways that a nutrient or bioactive ingredient can affect cognitive health. But which have the most science, how do they work?
Emerging targets to relieve fat stress-induced liver diseases: UDCA, tocotrienol, -3 PUFAs, and IgY targeted NPC1L1 cholesterol transporter.
Cha JY, Park JM, Lee HJ, Bae JS, Han YM, Oh BC, Ko KH, Hahm KB.
Curr Pharm Des. 2017 Jul 14. doi: 10.2174/1381612823666170714124824. [Epub ahead of print]
Abstract
Fat stress-induced liver disease is a hepatic manifestation of metabolic syndrome initiated by excess fat accumulation and encompasses a wide spectrum of diseases from non-alcoholic fatty liver disease to non-alcoholic steatohepatitis, a precursor lesion progressing to more aggressive liver cirrhosis and hepatocellular carcinoma. Although the incidence of these fat stress-induced liver diseases is rapidly increasing worldwide in parallel with the growing epidemics of obesity and metabolic diseases, its exact pathogenesis is not well defined. Although obesity, sedentary life-style, altered dietary pattern, insulin resistance, altered intestinal barrier function, inflammatory cytokines, and oxidative stress have been acknowledged as contributing factors because of the indefinite pathogenesis of metabolic diseases, the only reliable treatment is lifestyle intervention composed of restrictive diet and exercise. Additionally, some existing medications such as pioglitazone and antioxidants such as vitamin E were reported to be effective; in this review, several novel agents especifically targeting non-alcoholic fatty liver disease pathogenesis under clinical trial will be introduced. These include an NPC1L1 blocker (ezetimibe), which significantly improved histological and symptomatic scores associated with steatohepatitis and fibrosis; clofibrate, phentoxyfylline, ursodeoxycholic acid, and tocopherol, all of which are prescribed to relieve fat stress; and additional IgY targeted NPC1L1, tocotrienol, ursodeoxycholic acid, and -3 polyunsaturated fatty acids, which are actively under investigation to confirm the safety of long-term use.
Antioxidants might help in early diabetic kidney disease: Study
Supplementation with antioxidants like vitamin E could reduce the excretion of a specific protein in patients’ urine, which is an early sign of diabetic kidney disease (DKD), say researchers.
Potential role of natural compounds as anti-angiogenic agents in cancer.
Shanmugam MK, Warrier S, Kumar AP, Sethi G, Arfuso F.
Curr Vasc Pharmacol. 2017 Jul 12. doi: 10.2174/1570161115666170713094319. [Epub ahead of print]
Abstract
BACKGROUND:
Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark event in normal embryonic development as blood vessels generally supply both oxygen and nutrients to the cells of the body. Any disruption in this process can lead to the development of various chronic diseases, including cancer. In cancer, aberrant angiogenesis plays a prominent role in maintaining sustained tumor growth to malignant phenotypes and promoting metastasis. The leakiness in the tumor microvasculature is attributed to the tumor cells migrating to distal site organs and forming colonies.
METHODS:
In this article, we briefly review the various mediators involved in the angiogenic process and the anti-angiogenic potential of selected natural compounds against various malignancies.
RESULTS:
Several growth factors and their receptors such as vascular endothelial growth factor and receptor (VEGF/VEGFR), basic fibroblast growth factor and receptor (bFGF/FGFR), angiopoietins, and hypoxia inducible factors facilitate the development of angiogenesis and are attractive anti-cancer targets. Natural products represent a rich diversity of compounds for drug discovery and are currently being actively exploited to target tumor angiogenesis.
CONCLUSION:
Agents such as curcumin, artemisinin and its semi-synthetic derivatives, EGCG, pentacyclic triterpenoids, resveratrol, emodin, celastrol, thymoquinone and tocotrienols all have shown prominent anti-angiogenic effects in the preclinical models of tumor angiogenesis. Several semi-synthetic derivatives and novel nano-formulations of natural compounds have also exhibited excellent anti-angiogenic activity by increasing bioavailability and delivering the drugs to the sites of tumor angiogenesis.
The effect of almonds on vitamin E status and cardiovascular risk factors in Korean adults: a randomized clinical trial.
Jung H, Chen CO, Blumberg JB, Kwak HK.
Eur J Nutr. 2017 Jul 10. doi: 10.1007/s00394-017-1480-5. [Epub ahead of print]
Abstract
PURPOSE:
Almonds have shown to beneficially modify some cardiovascular risk factors in clinical trials conducted in diverse ethnic populations but this relationship has never been tested in Koreans. Thus, we tested the impact of almonds consumed as a snack within the context of a typical Korean diet on cardiovascular risk factors.
METHODS:
We conducted a randomized, crossover trial in a free-living setting with a 2-week run-in period, two 4-week intervention phases, and a 2-week washout period between interventions. Eighty four overweight/obese participants (11 M/73 F; 52.4 ± 0.6 year; 25.4 ± 0.22 kg/m2) consumed either 56 g of almonds or isocaloric cookies daily for 4 weeks.
RESULTS:
Mean % daily energy intake at baseline was 64.8, 21.3, and 14.9% from carbohydrate, fat, and protein, respectively. The addition of 56 g of almonds daily decreased carbohydrate energy to 55.0%, increased fat to 32.0%, and maintained protein at 14.7%. Consuming the almonds increased intake of MUFA by 192.3%, PUFA by 84.5%, vitamin E by 102.7%, and dietary fiber by 11.8% and decreased % energy from carbohydrate by 14.1%. Total caloric intake was increased by the almonds, but body weight, waist circumference, and body composition were not affected. Almonds in overweight and obese Korean adults decreased TC, LDL-C, and non-HDL-C by 5.5, 4.6, and 6.4%, respectively, compared to the cookie control (P ≤ 0.05). Almonds increased plasma α-tocopherol by 8.5% (P ≤ 0.05) from the baseline and tended to increase its value as compared to cookies (P = 0.055). Neither the almonds nor cookies altered plasma protein carbonyls, MDA or oxLDL. Of serum inflammatory markers, IL-10 was decreased by almond intake (P ≤ 0.05), and ICAM-1, IL-1β, and IL-6 tended to be lower with almonds, compared to the cookies.
CONCLUSIONS:
Almonds at 56 g/day consumed as a snack favorably modified the Korean diet by increasing MUFA, PUFA, vitamin E, and dietary fiber intake and decreasing % energy intake from carbohydrate. Almonds also enhanced plasma α-tocopherol status and serum TC and LDL-C in overweight and obese Koreans. Thus, including almonds in typical Korean diets as a snack can help healthy overweight/obese individuals improve nutritional status and reduce their risk for CVD.
Evaluation of the possible nephroprotective effects of vitamin E and rosuvastatin in amikacin-induced renal injury in rats.
Selim A, Khalaf MM, Gad AM, Abd El-Raouf OM.
J Biochem Mol Toxicol. 2017 Jul 6. doi: 10.1002/jbt.21957. [Epub ahead of print]
Abstract
Amikacin (AMIK) is an aminoglycoside antibiotic that possesses considerable nephrotoxic adverse effects. This study examined the protective effects of vitamin E (VIT. E) or rosuvastatin (ROSU) against AMIK-induced nephrotoxicity. For this purpose, eight groups of rats were used. Two control groups received saline and vehicle, AMIK group (1.2 g/kg, i.p.), VIT. E group (1000 mg/kg; p.o.), ROSU group (10 mg/kg; p.o.), AMIK + VIT. E group, AMIK + ROSU group, and combination group. The results showed that AMIK significantly increased serum levels of urea and creatinine. Meanwhile, serum levels of total protein and albumin were decreased. The kidney content of malondialdehyde was increased, whereas glutathione content and catalase activity were decreased. Tumor necrosis factor-α and nuclear transcriptional factor levels were increased. Conversely, administration of VIT. E and/or ROSU with AMIK ameliorated such damage and reduced DNA fragmentation, apoptosis, and necrosis. In conclusion, co-administration of VIT. E, ROSU, or their combination alleviated AMIK-induced nephrotoxicity.
H. Pylori Natural Treatment Protocol
Helicobacter pylori (H. pylori) can cause a wide range of problems, from chronic gastritis, peptic ulcer disease, iron deficiency anemia, and stomach cancer to diseases of the liver, cardiovascular system, skin, and many other body systems. If you suffer from this infection, an H. pylori natural treatment plan can be a safe solution. H. pylori infection is closely linked to coronary heart disease, rosacea, asthma, Parkinson’s disease, migraines, and fibromyalgia.
Herbal extracts and phytonutrients, many with antibacterial actions, are often used by natural practitioners to help eradicate H. pylori. itamin C, vitamin E, and selenium supplementation will help lower your risk of dying from stomach or esophageal cancer after H. pylori infection has been treated. This combination of antioxidant nutrients was studied in a large placebo controlled trial involving thousands of people with H. pylori.
