Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression
Wan Hasan WN, Chin KY, Abd Ghafar N, Soelaiman IN
Drug Des Devel Ther. 2020 Mar 3;14:969-976. doi: 10.2147/DDDT.S224941. eCollection 2020.
Abstract PURPOSE: Annatto-derived tocotrienol (AnTT) has been shown to improve bone formation in animal models of osteoporosis and promote differentiation of pre-osteoblastic cells. However, the mechanism of action of AnTT in achieving these effects is unclear. This study aims to investigate the mechanism of action of AnTT on MC3T3-E1 pre-osteoblasts via the mevalonate pathway. METHODS: Murine pre-osteoblastic Read more…