When vitamin E was discovered in 1922, it was discovered as alpha-tocopherol. Between that time and 1940, scientists delved into tocopherol research, ranging from alpha-tocopherol’s isolation from plants2, chemical identification3,4, complete synthesis5, and antioxidant activity6. In fact, the tocopherol form remained the main focus of vitamin E science for decades, and, as such, research on tocopherols boomed.7,8
Tocotrienols were discovered later, in the mid-1960s.9,10 Tocotrienols’ ability to lower lipids was first reported in the early 1980s; in the 1990s, tocotrienols were associated with reduction of cardiovascular diseases and inhibition of cancers.11 Despite the growing research on tocotrienols, they are still often confused with tocopherols and were not even properly listed in the Merck Index, the encyclopedia of chemicals, drugs, and biologicals, until 2001.12
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